APVV-15-0641

Principal investigator: Peter Šiffalovič
Principal investigator (IMPG SAS): Albert Breier

Duration: July 2016 – June 2020
Coordinating institution: Institute of Physics SAS

Annotation:

The goal of the proposed project is to develop a novel smart 2-dimensional multifunctional nanoplatform based on MoS2 for cancer cell detection and treatment. The MoS2 nanosheets prepared by liquid phase exfoliation and/or Li intercalation and modified for low toxicity and high biocompatibility will be chemically functionalized with antibodies sensitive to specific cancer cells and relevant cytotoxine. In comparison to graphene based nanosheets the MoS2 provides much stronger signal for the advanced laboratory diagnostics such as Raman spectroscopy, X-ray methods, SEM and TEM. Strong Raman signal and photoluminescence of MoS2 nanosheets will allow a label-free in situ tracking of the nanoplatform localization at the cell level. This will be one of the original project contributions to the knowledge of the cell interaction with the functional nanoplatform in general. The new quality of the laboratory testing of the nanoplatform interaction with the cancer cells may bring new knowledge and essential progress in the field of 2D nanoplatform generally. New knowledge is expected also in terms of a smart handling of biocompatibility and toxicity of the nanoplatform which is important for the nanoplatform cell internalization. Newly elaborated technological procedures will have direct implications for tailored 2D materials technology.

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