Ing. Martina Guzyová, PhD.

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Position:

Institute of Molecular Physiology and Genetics, Centre of Biosciences, Slovak Academy of Sciences, Bratislava, Slovak Republic, Research Fellow
Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic, Research Fellow

Qualification:

2011 BC., biotechnology, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic (supervisor: Ing. Svetlana Kryštofová, PhD.)
2013 MS., biotechnology, module medical engineering, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic (supervisor: Ing. Svetlana Kryštofová, PhD.)
2017 PhD., biochemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic (supervisor: doc. Ing. Albert Breier, DrSc.)
Thesis: The role of P-glycoprotein in reducing the sensitivity of leukemia cells to cytotoxic agents.

Techniques:

methods of DNA and RNA study (isolation of DNA and RNA, PCR, qPCR, cell lines transfection); methods of protein study (proteins isolation, SDS-PAGE, Western Blot, imunoprecipitation, determination of enzyme activity); FACS; search in bioinformatic databases; cultivation of cell lines

Support:

Slovak Research and Development Agency (APVV):
PGP APVV-14-0334
Possible dual function of P-glycoprotein in leukemia cells: efflux pump and regulatory protein (2015-2018)
team member; principal investigator: Zdena Sulová
Grants Agency for Science of the Slovak Republic (VEGA):
PGP VEGA 2/0122/17
Study of changes in expression of some regulatory and functional proteins connected with the presence of P-gp protein in leukemic cells (2017-2020)
team member; principal investigator: Zdena Sulová
PGP VEGA 2/0156/16
The effect of endoplasmic reticulum stress inductors and proteaosome inhibitors on leukemia cell line L1210, SKM-1 and MOLM-13 with induced P-glycoprotein overexpression (2016-2018)
team member; principal investigator: Mário Šereš
PGP VEGA 2/0028/15
Changes of leukemia cells drug sensitivity induced by changes of membrane drug transporters expression profile (2015-2017)
team member; principal investigator: Albert Breier