Laboratory uses patch clamp technique to investigate the role of voltage operated calcium channels with stress on cardiac and neuronal excitability. Current focus of the laboratory is on:

- Structure -function relation of T-type calcium channel
In cooperation with the group of prof. Norbert Klugbauer from the Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität, Freiburg, Germany we are constructing CaV3.1 channel mutants in order to investigate role of voltage sensor and pore structure in process of voltage dependent gating of the channel.

- Role of calcium channels in neuronal excitability.
We are investigating contribution of CaV1.2 and CaV1.3 L-type calcium channels to neuronal excitability and development on three models: PC12 cells; primary culture of rat neonatal hippocampal neurons; acutely isolated hippocampal cells from CaV1.2-/- mice (in cooperation with PD.D. Sven Moosmang, Institute of pharmacology and toxicology TU München, Germany).

- Pharmacology of voltage-dependent calcium channels.
In cooperation with various institutions we are investigating mechanisms underlying interaction of actual or potential pharmacological agents as well as common environmental contaminants with T-type and L-type calcium channels.