Projects

Scientific Secretary
RNDr. Viera Boháčová, CSc.

National

Current
  • DNA methylation changes accompanying the development of multidrug resistance
    Program: VEGA
    Duration: 1. 1. 2024 – 31. 12. 2027
  • -
    Program: VEGA
    Duration: 1. 1. 2023 – 31. 12. 2026
  • The effect of UV-B radiation on DNA damage and repair mechanisms in the P-glycoprotein-expressing L1210 cell line
    Program: VEGA
    Duration: 1. 1. 2022 – 31. 12. 2025
  • Molecular mechanisms of trialkyl-/triaryltin isothiocyanates\' and carboxylates\' antitumour properties - novel ligands of nuclear retinoid X receptors in rat mammary gland carcinomas and human tumour cell lines
    Program: SRDA
    Duration: 1. 7. 2021 – 30. 6. 2025
  • Defense mechanisms of microbial and animal cells in reducing their sensitivity to plant defensive compounds
    Program: SRDA
    Duration: 1. 7. 2020 – 30. 6. 2024
  • Multidrug resistance of leukemia cells - Phenotype caused by interference of multimodal molecular reasons
    Program: SRDA
    Duration: 1. 7. 2020 – 30. 6. 2024
Finished
  • Study of alteration in leukemia cells phenotype after induction of ABCB1 membrane transporter
    Program: VEGA
    Duration: 1. 1. 2019 – 31. 12. 2022
  • Effect of endoplasmic reticulum-stress inducing substances on cell cycle regulatory mechanisms in cell lines with MDR phenotype
    Program: VEGA
    Duration: 1. 1. 2019 – 31. 12. 2021
  • The effect of polyphenols on the functions of signal proteins involved in proteins N-glycosylation in the endoplasmic reticulum of leukemia cells, depending on the expression of P-glycoprotein
    Program: VEGA
    Duration: 1. 1. 2018 – 31. 12. 2021
  • The effect of endoplasmic reticulum stress inductors and proteaosome inhibitors on leukemia cell line L1210, SKM-1 and MOLM-13 with induced P-glycoprotein overexpression
    Program: VEGA
    Duration: 1. 1. 2016 – 31. 12. 2018
  • Changes of leukemia cells drug sensitivity induced by changes of membrane drug transporters expression profile.
    Program: VEGA
    Duration: 1. 1. 2015 – 31. 12. 2018
  • Alternation in cell metabolism asocciated with drug transporter P-glycoprotein overexpression in leukemia cells
    Program: SRDA
    Duration: 1. 5. 2011 – 31. 10. 2014
  • Changes of leukemia cells associated with P-glycoprotein mediated multidrug resistance development
    Program: VEGA
    Duration: 1. 1. 2009 – 31. 12. 2011
  • Study of the interactive binding site of P-glycoprotein with pentoxifylline derivatives
    Program: VEGA
    Duration: 1. 1. 2007 – 31. 12. 2009
  • Changes of neoplastic cell metabolism associated with development of p-glycoprotein mediated miltidrug resistance induced by adaptation of sensitive cells to drugs
    Program: VEGA
    Duration: 1. 1. 2007 – 31. 12. 2009
Employees