Completed Projects

2012-2016

International projects:
VEGA_0107_0019_DAAD DAAD/SAV
Novel interaction partners of the Cav2.2 channel (2016 –2017)
Principal Investigator: Ľubica Lacinová
Obr2Home SASPRO 0063/01/02
Mitochondria-endoplasmic reticulum functional interplay in Wolfram Syndrome: emerging role for heart and brain protection (2015-2018)
Principal Investigator: Michal Cagalinec
PGP Project CELGENE (2009-2014)
Principal Investigator: Albert Breier (Contract with the Celgene company).
COST BM1005
Gasotransmitters: from basic science to therapeutic applications (2011-2015)
Principal Investigator (University of Athens Dept of Pharmacy, Athens, Greece): Prof. Andreas Papapetropoulos
Principal Investigator at IMPG SAS: Karol Ondriáš
COST TD0901
Hypoxia and oxygen sensing, signaling and adaptation (2009-2013)
Principal Investigator (Institute of Physiology, University of Zurich, Zurich): Prof. Roland H. Wenger
Principal Investigator at IMPG SAS: Oľga Križanová

Slovak Research and Development Agency (APVV):
sparks APVV-15-0302
Cytoarchitecture of calcium signalling of cardiac myocytes in development of myocardial hypertrophy (2016 – 2019)
Principal Investigator: Alexandra Zahradníková
reticulum APVV-SK-FR-2015-0007
Effect of endoplasmic reticulum stress on ultrastructure and metabolism of mammalian cardiomyocytes (2016 – 2017)
Principal Investigator: Marta Novotová
Coordinated at IMPG SAS
image APVV-0721-10
Myocardial remodelling – the role of calcium signalling (REMOD) (2011 – 2014)
Principal Investigator: Alexandra Zahradníková
PGP APVV-0290-10
Alteration in cell metabolism asocciated with drug transporter P-glycoprotein overexpression in leukemia cells (2011-2014)
Principal Investigator: Zdena Sulová
image APVV-0212-10
Calcium channels in neuronal excitability (2011 – 2014)
Principal Investigator: Ľubica Lacinová
APVV-0160-11
Antitumour effect of biologically active ligands of nuclear retinoid X receptor heterodimers in tissue carcinoma cell lines (2012-2015)
Principal Investigator (Institute of experimental Endocrinology, SAS): Július Brtko
Principal Investigator at IMPG SAS: Zdena Sulová
SK-FR-0014-11
Study of channel properties of novel crown ethers containing polymers in lipid membranes (2012 – 2014)
Principal Investigator: Karol Ondriaš
mito3 APVV-SK-FR-0021-11
Energetic cross-talk and cytoarchitecture of cardiac myocytes. Role of the mitochondrial protein OPA1. (2012 – 2013)
Principal Investigator: Marta Novotová
APVV4b APVV-LPP-0441-09
Mechanisms of ryanodine receptor dysregulation (2009 – 2012)
Principal Investigator: Alexandra Zahradnikova
Collaborative projects
APVV-0282-11
Preparation of nanostructured interfaces, their integration with bioelements and subsequent use (2012-2015)
Principal Investigator (Institute of Chemistry, SAS): Ján Tkáč
Principal Investigator at IMPG SAS: Zdena Sulová
APVV_0240 APVV-0240-12
Functional analysis of newly identified DNA variants in genes responsible for cystic fibrosis and fenylketonuria (2013 – 2016)
Team leader: Ľubica Lacinová

Grant Agency for Science (VEGA):
image VEGA 2/0024/15
Effects of stress, induced by immune challenge during the gestation in rats, on maternal care behaviour and on hippocampal neuronal excitability in the offsprings (2015 – 2017)
Principal Investigator: Eliyahu Dremencov
BLM VEGA 2/0006/15
The role of physiologically relevant metal ions Mg2+ and Zn2+ in the luminal regulation of the cardiac ryanodine receptor (2015 – 2017)
Principal Investigator: Jana Gaburjáková
reticulum VEGA 2/0110/15
The effect of myocardial load on distribution of the endoplasmic membrane reticulum of cardiac myocytes (2015 – 2017)
Principal Investigator: Marta Novotová
confocal VEGA 2/0095/15
Expression and co-localization of dyadic protein complexes in ventricular myocytes in relation to excitation-contraction coupling ontogenesis (2015 – 2017)
Principal Investigator: Alexandra Zahradníková, jr.
wave VEGA 2/0143/17
Diastolic function of the ryanodine receptor and generation of arrhythmogenic calcium waves (2017 – 2019)
Principal investigator: Alexandra Zahradnikova
Obr2Home VEGA 2/0169/16
Mitochondrial dynamics and morphology in transgenic model of Wolfram syndrome: emerging role for heart protection (2016 – 2018)
Principal Investigator: Michal Cagalinec
struct VEGA 2/0148/14
Structure-function relationships of the ryanodine receptor (2014-2016)
Principal Investigator: Alexandra Zahradníková
sparks VEGA 2/0147/14
Development of dyadic calcium signaling during postnatal maturation of ventricular myocytes (2014-2016)
Principal Investigator: Ivan Zahradník
BLM VEGA 2/0003/14
The role of calsequestrin in luminal regulation of the cardiac ryanodine receptor (2014 – 2016)
Principal Investigator: Marta Gaburjáková
PGP VEGA 2/0182/13
Multidrug resistance of leukemia cells on different drugs (2013-2016)
Principal Investigator: Zdena Sulová
image VEGA 2/0044/13
Principle of gating of voltage-dependent calcium channels (2013 – 2015)
Principal Investigator: Ľubica Lacinová
membranes VEGA 2/0116/12
Plasticity of the membrane systems of cardiac myocytes (2012 – 2014)
Principal investigator: Marta Novotova
image VEGA 2/0102/12
Competition between Ca2+ and other cation for luminally located binding site on the cardiac ryanodine receptor and its effect on the receptor regulation (2012 – 2014)
Principal Investigator: Jana Gaburjáková
PGP VEGA 2/0100/12
Overexpression of P-glycoprotein-induced cell changes in leukemia cells (2012-2014)
Principal Investigator: Albert Breier
VEGA 2/0094/12
Study of redox and radical regulation of mitochondrial chloride channels from rat heart under oxidative stress (2012-2014)
Principal Investigator: Zuzana Tomášková
VEGA 2/0027/12
Molecular analysis of HGD gene and establishment of in vitro model for studying of potential therapeutic agents in pacients with alkaptonuria (2012-2014)
Principal Investigator: Ján Radvánszky
conductance VEGA 2/0203/11
Sarcolemmal and membrane conductance dynamics in cardiac myocytes (2011 – 2013)
Principal investigator: Ivan Zahradnik
image VEGA 2/0197/11
Mechanisms of communication among ion channels of cardiomyocyte dyad (2011 – 2013)
Principal investigator: Alexandra Zahradnikova, Jr., Jana Pavelkova
image VEGA 2/0097/11
Modulation and function of inositol 1,4,5-trisphosphate receptors (IP3R) in neuronal structures of central nervous system (CNS) in normal and pathological conditions (2011 – 2013)
Principal Investigator: Michaela Pavlovičová
image VEGA 2/0033/11
Determinants of coupled gating among cardiac ryanodine receptors (2011 – 2013)
Principal Investigator: Marta Gaburjáková
VEGA 1/0726/10
The effect of beta-blockers on electrical activity and ultrastructure of myocardium after isoprenaline-induced remodeling (2010 – 2012)
Principal Investigator (Pharmaceutical Faculty of Comenius University): Tatiana Stankovičová
Principal Investigator at IMPG SAS: Marta Novotová
image VEGA 2/0195/10
Regulation of the gating of the T-type calcium channel (2010 – 2012)
Principal Investigator: Ľubica Lacinová
wave VEGA 2/0190/10
Mechanisms of regulation of the diastolic activity of the ryanodine receptor (2010 – 2012)
Principal investigator: Alexandra Zahradnikova
VEGA 2/0169/10
Preparation of new xanthine derivatives capable to effective reverse P-glycoproteine mediated multidrug resistance and monitoring their mechanism of influence on resistance (2010 – 2012)
Principal Investigator: Peter Dočolomanský
VEGA 2/0150/10
Modulation of rat heart mitochondrial channels by hydrogen sulfide (2010 – 2012)
Principal Investigator: Karol Ondriaš
PGP VEGA 2/0123/10
The effect of P-glycoprotein and development of multidrug resistance on some aspects of metabolism (2010-2012)
Principal Investigator: Zdena Sulová
VEGA 2/0104/10
Mutation scanning of the gene responsible for neurofibromatosis type 1 (2010 – 2012)
Principal Investigator: Ľudevít Kádaši
VEGA 2/0082/10
Investigation of the relationship between Na+/Ca2+ exchanger ond other calcium transport systems (2010 – 2012)
Principal Investigator: Soňa Hudecová
VEGA 2/0049/10
Mechanism of regulation of individual types of IP3 receptors and their function (2010 – 2012)
Principal Investigator: Oľga Križanová

Center of excellence SAS:
CEMAN – Center of excellence for the study of metabolic aspects of development, diagnostics and treatment of cancer diseases (2011 – 2014)
Principal Investigator: Oľga Križanová

Selected older projects

International projects:
image MRTN-CT-2006-035367 6RP Marie Curie Research Training Network
CavNet L-type calcium channels in health and disease (2006 – 2010)
Coordinator: Hearing Research Centre Tübingen, Eberhard Karls University, Tübingen, Germany
Team Leader: Ľubica Lacinová
image LSHM-CT-2005-018833
Genomics of cardiomyocyte signalling to treat and prevent heart failure (2006-2010)
Coordinator: Gerd Hasenfuss, University of Göttingen
Team leader: Alexandra Zahradníková
wave LSHM-CT-2005-018802
Control of Intracellular Calcium in Arrhythmias (2006-2009)
Coordinator: Burkert Pieske, University of Göttingen / University of Graz
Team leader: Alexandra Zahradníková
PGP NATO Grant PDD(CP)-(CBP.NUKR.CLG 982646)
P-glycoprotein Mediated Multidrug Resistance in Radiation-Associated Hematological Malignancies Following the Chernobil Accident (2007-2008)
Principal Investigator: Albert Breier
wave NIH FIRCA RO3 TW005543/2
Reorganization of calcium signaling in heart failure (2005-2008)
Principal Investigator: Sandor Gyorke, Ohio State University, Columbus, OH, USA
International Collaborator: Alexandra Zahradníková, Ivan Zahradník
NIH FIRCA 2R03TW000949-04A1
Coupled gating between intracellular calcium release channels (2002-2004)
Principal Investigator: Prof. Andrew R. Marks, M.D., Columbia University, NY, USA
International Collaborator: Karol Ondriaš
NATO grant SA LST.CLG.979217
Role of mitochondrial channels in cardioprotection (2002-2005)
Principal Investigator: Prof. Szewczyk Adam, PhD., DSc., Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
International Collaborator: Karol Ondriaš
image Volkswagen grant
Role of L-type and T-type Ca2+ channels in neuronal excitability (2002 – 2004)
Principal Investigator: prof. Franz Hofmann, Institute for Pharmacology and Toxicology, Munich,Germany
International Collaborator: Ľubica Lacinová
image NIH FIRCA RO3 TW005543/1
Calcium signalling in cardiac excitation-contraction coupling (2001-2004)
Principal Investigator: Sandor Gyorke, Texas Tech University, Lubbock, TX, USA
International Collaborator: Alexandra Zahradníková, Ivan Zahradník
image HHMI-55000343
Molecular mechanisms of calcium signaling in cardiac excitation-contraction coupling (2001-2005)
Principal Investigator: Alexandra Zahradníková
image NIH FIRCA R03 TW 00949
Coupled gating between intracellular calcium release channels (1998 – 2005)
Principal Investigator: Andrew R. Marks, Columbia University, New York, NY, USA
International Collaborators: Karol Ondriáš, Marta Gaburjáková
APVV4b HHMI-75195547801
Ryanodine receptor and excitation-contraction coupling (1995-2000)
Principal Investigator: Alexandra Zahradníková

Slovak Research and Development Agency (APVV):
myo APVV-SK-CZ-0172-09
Cell and molecular physiology of cardiomyocytes (2010 – 2011)
Principal Investigator: Alexandra Zahradnikova
image VVCE-0064-07
Biomembranes: structure and dynamics of biological membranes related to the cell functions (2008 – 2011)
Principal Investigator: Ivan Hapala, Institute of Animal Biochemistry and Genetics SAS, Slovak Republic
Team Leader: Ľubica Lacinová
APVV-0084-07
Overexpression of P-glycoprotein and associated changes in spectrum and levels of oligo- and polysacharides (2008 – 2010)
Principal Investigator: Zdena Sulová
RyR APVV-0139-06
SaFRyR: Structure-function relationships of the ryanodine receptor domains involved in CPVT arrhythmias (2007 – 2009)
Principal Investigator: Jozef Ševčík
Team Leader: Alexandra Zahradníková
LPP-0099-06
Abnormal cytosolic and luminal calcium signalling in heart failure (2007 – 2008)
Principal Investigator: Alexandra Zahradníková
image APVT-51-031104
Mechanism of excitation-contraction coupling in normal and failing mammalian myocardium (2005 – 2007)
Principal Investigator: Ivan Zahradník

Center of excellence SAS:
CEKVY – Center of excellence for cardiovascullar research (2007 – 2010)
Principal Investigator: Oľga Križanová

Other domestic grants:
BITCET State program 2003SP200028201
Building of the biotechnology centre – BITCET (2003-2010)
Principal Investigator (Institute of Virology SAS): Jaroslav Pastorek
Principal Investigator at IMPG SAS: Albert Breier
State program SP51/0280800/0280802
Genomics of cardiovascular diseases for healthier human population (2002 – 2005)
Principal Investigator: Oľga Križanová
image KEGA 3/7389/09
Biopysical principles of voltage dependent ion channels regulation in health and disease (2009 – 2011) Coordinator: Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic
Collaborator: Ľubica Lacinová
image ESF Project
BIOMEMBRANES: Education program for PhD students and young scientists from biological and biomedical sciences (2006 – 2008)
Principal Investigator: Ivan Hapala, Institute of Animal Biochemistry and Genetics SAS, Slovak Republic
Team Leader: Ľubica Lacinová