2012-2016
International projects: |
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DAAD/SAV Novel interaction partners of the Cav2.2 channel (2016 –2017) Principal Investigator: Ľubica Lacinová |
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SASPRO 0063/01/02 Mitochondria-endoplasmic reticulum functional interplay in Wolfram Syndrome: emerging role for heart and brain protection (2015-2018) Principal Investigator: Michal Cagalinec |
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Project CELGENE (2009-2014) Principal Investigator: Albert Breier (Contract with the Celgene company). |
COST BM1005 Gasotransmitters: from basic science to therapeutic applications (2011-2015) Principal Investigator (University of Athens Dept of Pharmacy, Athens, Greece): Prof. Andreas Papapetropoulos Principal Investigator at IMPG SAS: Karol Ondriáš |
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COST TD0901 Hypoxia and oxygen sensing, signaling and adaptation (2009-2013) Principal Investigator (Institute of Physiology, University of Zurich, Zurich): Prof. Roland H. Wenger Principal Investigator at IMPG SAS: Oľga Križanová |
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Slovak Research and Development Agency (APVV): |
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APVV-15-0302 Cytoarchitecture of calcium signalling of cardiac myocytes in development of myocardial hypertrophy (2016 – 2019) Principal Investigator: Alexandra Zahradníková |
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APVV-SK-FR-2015-0007 Effect of endoplasmic reticulum stress on ultrastructure and metabolism of mammalian cardiomyocytes (2016 – 2017) Principal Investigator: Marta Novotová |
Coordinated at IMPG SAS | |
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APVV-0721-10 Myocardial remodelling – the role of calcium signalling (REMOD) (2011 – 2014) Principal Investigator: Alexandra Zahradníková |
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APVV-0290-10 Alteration in cell metabolism asocciated with drug transporter P-glycoprotein overexpression in leukemia cells (2011-2014) Principal Investigator: Zdena Sulová |
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APVV-0212-10 Calcium channels in neuronal excitability (2011 – 2014) Principal Investigator: Ľubica Lacinová |
APVV-0160-11 Antitumour effect of biologically active ligands of nuclear retinoid X receptor heterodimers in tissue carcinoma cell lines (2012-2015) Principal Investigator (Institute of experimental Endocrinology, SAS): Július Brtko Principal Investigator at IMPG SAS: Zdena Sulová |
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SK-FR-0014-11 Study of channel properties of novel crown ethers containing polymers in lipid membranes (2012 – 2014) Principal Investigator: Karol Ondriaš |
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APVV-SK-FR-0021-11 Energetic cross-talk and cytoarchitecture of cardiac myocytes. Role of the mitochondrial protein OPA1. (2012 – 2013) Principal Investigator: Marta Novotová |
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APVV-LPP-0441-09 Mechanisms of ryanodine receptor dysregulation (2009 – 2012) Principal Investigator: Alexandra Zahradnikova |
Collaborative projects | |
APVV-0282-11 Preparation of nanostructured interfaces, their integration with bioelements and subsequent use (2012-2015) Principal Investigator (Institute of Chemistry, SAS): Ján Tkáč Principal Investigator at IMPG SAS: Zdena Sulová |
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APVV-0240-12 Functional analysis of newly identified DNA variants in genes responsible for cystic fibrosis and fenylketonuria (2013 – 2016) Team leader: Ľubica Lacinová |
Grant Agency for Science (VEGA): |
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VEGA 2/0024/15 Effects of stress, induced by immune challenge during the gestation in rats, on maternal care behaviour and on hippocampal neuronal excitability in the offsprings (2015 – 2017) Principal Investigator: Eliyahu Dremencov |
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VEGA 2/0006/15 The role of physiologically relevant metal ions Mg2+ and Zn2+ in the luminal regulation of the cardiac ryanodine receptor (2015 – 2017) Principal Investigator: Jana Gaburjáková |
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VEGA 2/0110/15 The effect of myocardial load on distribution of the endoplasmic membrane reticulum of cardiac myocytes (2015 – 2017) Principal Investigator: Marta Novotová |
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VEGA 2/0095/15 Expression and co-localization of dyadic protein complexes in ventricular myocytes in relation to excitation-contraction coupling ontogenesis (2015 – 2017) Principal Investigator: Alexandra Zahradníková, jr. |
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VEGA 2/0143/17 Diastolic function of the ryanodine receptor and generation of arrhythmogenic calcium waves (2017 – 2019) Principal investigator: Alexandra Zahradnikova |
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VEGA 2/0169/16 Mitochondrial dynamics and morphology in transgenic model of Wolfram syndrome: emerging role for heart protection (2016 – 2018) Principal Investigator: Michal Cagalinec |
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VEGA 2/0148/14 Structure-function relationships of the ryanodine receptor (2014-2016) Principal Investigator: Alexandra Zahradníková |
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VEGA 2/0147/14 Development of dyadic calcium signaling during postnatal maturation of ventricular myocytes (2014-2016) Principal Investigator: Ivan Zahradník |
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VEGA 2/0003/14 The role of calsequestrin in luminal regulation of the cardiac ryanodine receptor (2014 – 2016) Principal Investigator: Marta Gaburjáková |
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VEGA 2/0182/13 Multidrug resistance of leukemia cells on different drugs (2013-2016) Principal Investigator: Zdena Sulová |
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VEGA 2/0044/13 Principle of gating of voltage-dependent calcium channels (2013 – 2015) Principal Investigator: Ľubica Lacinová |
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VEGA 2/0116/12 Plasticity of the membrane systems of cardiac myocytes (2012 – 2014) Principal investigator: Marta Novotova |
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VEGA 2/0102/12 Competition between Ca2+ and other cation for luminally located binding site on the cardiac ryanodine receptor and its effect on the receptor regulation (2012 – 2014) Principal Investigator: Jana Gaburjáková |
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VEGA 2/0100/12 Overexpression of P-glycoprotein-induced cell changes in leukemia cells (2012-2014) Principal Investigator: Albert Breier |
VEGA 2/0094/12 Study of redox and radical regulation of mitochondrial chloride channels from rat heart under oxidative stress (2012-2014) Principal Investigator: Zuzana Tomášková |
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VEGA 2/0027/12 Molecular analysis of HGD gene and establishment of in vitro model for studying of potential therapeutic agents in pacients with alkaptonuria (2012-2014) Principal Investigator: Ján Radvánszky |
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VEGA 2/0203/11 Sarcolemmal and membrane conductance dynamics in cardiac myocytes (2011 – 2013) Principal investigator: Ivan Zahradnik |
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VEGA 2/0197/11 Mechanisms of communication among ion channels of cardiomyocyte dyad (2011 – 2013) Principal investigator: Alexandra Zahradnikova, Jr., Jana Pavelkova |
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VEGA 2/0097/11 Modulation and function of inositol 1,4,5-trisphosphate receptors (IP3R) in neuronal structures of central nervous system (CNS) in normal and pathological conditions (2011 – 2013) Principal Investigator: Michaela Pavlovičová |
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VEGA 2/0033/11 Determinants of coupled gating among cardiac ryanodine receptors (2011 – 2013) Principal Investigator: Marta Gaburjáková |
VEGA 1/0726/10 The effect of beta-blockers on electrical activity and ultrastructure of myocardium after isoprenaline-induced remodeling (2010 – 2012) Principal Investigator (Pharmaceutical Faculty of Comenius University): Tatiana Stankovičová Principal Investigator at IMPG SAS: Marta Novotová |
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VEGA 2/0195/10 Regulation of the gating of the T-type calcium channel (2010 – 2012) Principal Investigator: Ľubica Lacinová |
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VEGA 2/0190/10 Mechanisms of regulation of the diastolic activity of the ryanodine receptor (2010 – 2012) Principal investigator: Alexandra Zahradnikova |
VEGA 2/0169/10 Preparation of new xanthine derivatives capable to effective reverse P-glycoproteine mediated multidrug resistance and monitoring their mechanism of influence on resistance (2010 – 2012) Principal Investigator: Peter Dočolomanský |
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VEGA 2/0150/10 Modulation of rat heart mitochondrial channels by hydrogen sulfide (2010 – 2012) Principal Investigator: Karol Ondriaš |
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VEGA 2/0123/10 The effect of P-glycoprotein and development of multidrug resistance on some aspects of metabolism (2010-2012) Principal Investigator: Zdena Sulová |
VEGA 2/0104/10 Mutation scanning of the gene responsible for neurofibromatosis type 1 (2010 – 2012) Principal Investigator: Ľudevít Kádaši |
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VEGA 2/0082/10 Investigation of the relationship between Na+/Ca2+ exchanger ond other calcium transport systems (2010 – 2012) Principal Investigator: Soňa Hudecová |
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VEGA 2/0049/10 Mechanism of regulation of individual types of IP3 receptors and their function (2010 – 2012) Principal Investigator: Oľga Križanová |
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Center of excellence SAS: |
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CEMAN – Center of excellence for the study of metabolic aspects of development, diagnostics and treatment of cancer diseases (2011 – 2014) Principal Investigator: Oľga Križanová |
Selected older projects
International projects: |
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MRTN-CT-2006-035367 6RP Marie Curie Research Training Network CavNet L-type calcium channels in health and disease (2006 – 2010) Coordinator: Hearing Research Centre Tübingen, Eberhard Karls University, Tübingen, Germany Team Leader: Ľubica Lacinová |
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LSHM-CT-2005-018833 Genomics of cardiomyocyte signalling to treat and prevent heart failure (2006-2010) Coordinator: Gerd Hasenfuss, University of Göttingen Team leader: Alexandra Zahradníková |
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LSHM-CT-2005-018802 Control of Intracellular Calcium in Arrhythmias (2006-2009) Coordinator: Burkert Pieske, University of Göttingen / University of Graz Team leader: Alexandra Zahradníková |
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NATO Grant PDD(CP)-(CBP.NUKR.CLG 982646) P-glycoprotein Mediated Multidrug Resistance in Radiation-Associated Hematological Malignancies Following the Chernobil Accident (2007-2008) Principal Investigator: Albert Breier |
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NIH FIRCA RO3 TW005543/2 Reorganization of calcium signaling in heart failure (2005-2008) Principal Investigator: Sandor Gyorke, Ohio State University, Columbus, OH, USA International Collaborator: Alexandra Zahradníková, Ivan Zahradník |
NIH FIRCA 2R03TW000949-04A1 Coupled gating between intracellular calcium release channels (2002-2004) Principal Investigator: Prof. Andrew R. Marks, M.D., Columbia University, NY, USA International Collaborator: Karol Ondriaš |
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NATO grant SA LST.CLG.979217 Role of mitochondrial channels in cardioprotection (2002-2005) Principal Investigator: Prof. Szewczyk Adam, PhD., DSc., Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland International Collaborator: Karol Ondriaš |
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Volkswagen grant Role of L-type and T-type Ca2+ channels in neuronal excitability (2002 – 2004) Principal Investigator: prof. Franz Hofmann, Institute for Pharmacology and Toxicology, Munich,Germany International Collaborator: Ľubica Lacinová |
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NIH FIRCA RO3 TW005543/1 Calcium signalling in cardiac excitation-contraction coupling (2001-2004) Principal Investigator: Sandor Gyorke, Texas Tech University, Lubbock, TX, USA International Collaborator: Alexandra Zahradníková, Ivan Zahradník |
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HHMI-55000343 Molecular mechanisms of calcium signaling in cardiac excitation-contraction coupling (2001-2005) Principal Investigator: Alexandra Zahradníková |
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NIH FIRCA R03 TW 00949 Coupled gating between intracellular calcium release channels (1998 – 2005) Principal Investigator: Andrew R. Marks, Columbia University, New York, NY, USA International Collaborators: Karol Ondriáš, Marta Gaburjáková |
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HHMI-75195547801 Ryanodine receptor and excitation-contraction coupling (1995-2000) Principal Investigator: Alexandra Zahradníková |
Slovak Research and Development Agency (APVV): |
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APVV-SK-CZ-0172-09 Cell and molecular physiology of cardiomyocytes (2010 – 2011) Principal Investigator: Alexandra Zahradnikova |
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VVCE-0064-07 Biomembranes: structure and dynamics of biological membranes related to the cell functions (2008 – 2011) Principal Investigator: Ivan Hapala, Institute of Animal Biochemistry and Genetics SAS, Slovak Republic Team Leader: Ľubica Lacinová |
APVV-0084-07 Overexpression of P-glycoprotein and associated changes in spectrum and levels of oligo- and polysacharides (2008 – 2010) Principal Investigator: Zdena Sulová |
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APVV-0139-06 SaFRyR: Structure-function relationships of the ryanodine receptor domains involved in CPVT arrhythmias (2007 – 2009) Principal Investigator: Jozef Ševčík Team Leader: Alexandra Zahradníková |
LPP-0099-06 Abnormal cytosolic and luminal calcium signalling in heart failure (2007 – 2008) Principal Investigator: Alexandra Zahradníková |
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APVT-51-031104 Mechanism of excitation-contraction coupling in normal and failing mammalian myocardium (2005 – 2007) Principal Investigator: Ivan Zahradník |
Center of excellence SAS: |
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CEKVY – Center of excellence for cardiovascullar research (2007 – 2010) Principal Investigator: Oľga Križanová |
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Other domestic grants: |
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State program 2003SP200028201 Building of the biotechnology centre – BITCET (2003-2010) Principal Investigator (Institute of Virology SAS): Jaroslav Pastorek Principal Investigator at IMPG SAS: Albert Breier |
State program SP51/0280800/0280802 Genomics of cardiovascular diseases for healthier human population (2002 – 2005) Principal Investigator: Oľga Križanová |
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KEGA 3/7389/09 Biopysical principles of voltage dependent ion channels regulation in health and disease (2009 – 2011) Coordinator: Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic Collaborator: Ľubica Lacinová |
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ESF Project BIOMEMBRANES: Education program for PhD students and young scientists from biological and biomedical sciences (2006 – 2008) Principal Investigator: Ivan Hapala, Institute of Animal Biochemistry and Genetics SAS, Slovak Republic Team Leader: Ľubica Lacinová |